Engineering replacement tissue to reverse damage to the central nervous system
BE Therapeutics is an early-stage biotech startup, developing technology to engineer functional brain and spinal cord tissue. Our mission is to engineer your very own replacement tissue to reverse age-related and other forms of damage to ensure indefinite function.
Stroke, trauma, neurodegeneration, and aging all cause permanent damage to the CNS.
No treatments enable afflicted individuals to regain lost functions.
BE Therapeutics aims to change this.
SUPPORTERS
TECHNOLOGY
Rather than try and re-invent the wheel, the technology at BE Therapeutics is guided by how our human brains first developed during the early stages. Namely, BE Therapeutics is engineering a precursor tissue that mimics normal developmental brain tissue, with the proper cell types, signaling cues, and structure, which allow this tissue to mature normally after transplantation, integrate with the host, and encode useful information for the patient.
BE Therapeutics' tissue and methodologies will be used in pre-clinical and clinical applications. The initial focus is on replacing damaged neocortical tissue, followed by other parts of the CNS.
Multi-cell type structured brain tissue
MEET THE TEAM
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Chief Scientific Officer
Philip is a serial entrepreneur, building companies that develop new therapies for neurological diseases. Leveraging over 20 years of experience in cell and gene therapy, Philip has developed iPSC -derived cell products to treat Type 1 diabetes, neurodegenerative diseases and liver diseases at Smith Therapeutics, AZTherapies, Sigilon Therapeutics and Flagship Pioneering.
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Senior Clinical Advisor
Dr. David J. Altschul, MD, FAANS, FCNS, serves as the Chief of the Division of Cerebrovascular Neurosurgery, Surgical Director of the Comprehensive Stroke Center, Associate Residency Program Director, and Professor of Neurosurgery and Radiology at Montefiore-Einstein. He is a dual trained open-endovascular neurosurgeon, having completed his neurosurgical residency at Montefiore-Einstein and a neuroendovascular fellowship under the guidance of Dr. Alejandro Berenstein at Mt. Sinai.
Throughout his esteemed career, Dr. Altschul has garnered recognition for his exceptional patient care and unwavering commitment to excellence in neurovascular surgery. Renowned for his innovative treatment approach, he leverages cutting-edge technology and research to ensure optimal care for his patients. Actively engaged in numerous research initiatives focusing on new device developments and clinical trials, he has established a thriving Cerebrovascular research lab at Montefiore-Einstein. Dr. Altschul takes great pride in his dedication to mentorship, consistently offering his time to guide students at various stages of their learning journeys.
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SENIOR TISSUE ENGINEER
Wyndham began his scientific career studying Physics at the College of William & Mary in Williamsburg, VA; it was during this time that he had his first experience conducting research in biology and biophysics. Following his interest in applying techniques from the physical sciences to the biological world, Wyndham then completed his PhD in Biomedical Engineering at the University of Miami under Dr. Noel Ziebarth, where he was awarded the Graduate School Dean’s Fellowship.
After graduation, Wyndham furthered his training in stem cell biology and regenerative medicine as a Postdoctoral Fellow at the National Institutes of Health under Dr. Tiansen Li, where he learned to utilize functional biomaterials to direct the growth and behavior of human stem cell derived retinal organoids.
Wyndham now serves as the Senior Tissue Engineer at BE Therapeutics where he is developing novel biomaterial constructs for the creation of new functional brain tissue to be engrafted into damaged areas of the human brain.
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SCIENTIST
Anna’s passion for neuroscience stems from her intrigue of how the biological building blocks in the brain give rise to complex thoughts and behaviors. To pursue this, she first received her BS in Neuroscience at New York University. During her undergraduate years, she conducted molecular neuroscience and behavioral research at New York University, the City University of New York, the University of Wisconsin, and Vanderbilt University. Her research was funded by fellowships from the National Science Foundation and the National Institutes of Health. Anna then received her PhD in Neuroscience from Johns Hopkins University.
During her doctoral work with Dr. Jeremiah Cohen, she used an interdisciplinary approach to combine electrophysiology, molecular biology, and behavior to further investigate the link between the brain and behavior. At BE Therapeutics, Anna is a Scientist with a focus on in vivo, behavioral, and electrophysiology research.
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SCIENTIST
Monika was fascinated with regenerative medicine since she was an undergraduate student of Biotechnology in Szczecin, Poland. Her fascination with soft tissue engineering led her into multiple internships, including Wageningen University in the Netherlands, Polish Academy of Sciences, and Warsaw University of Technology. Monika focused on mastering biological approaches combined with biomaterials and precise deposition by 3D bioprinting. Monika’s PhD work at the Pennsylvania State University under professorship of Dr. Jeffrey Catchmark, was focused on innovative biomaterials and bioprinted functional pancreas-on-a-chip device.
After graduation Monika joined Biomics lab at CEA in Grenoble, France for a PostDoctoral project under mentorship of Prof. Xavier Gidrol, where she focused on PDAC initiation in a diabetic microenvironment. Following her interest in soft tissue engineering, Monika joined 3DBio Therapeutics company, where she was developing and translating innovative biological products and technologies from R&D to the clinic.
At BE Therapeutics, Monika is a Scientist with a focus on biomaterials development and vascularization in vivo for the neocortex repair.
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SENIOR STEM CELL SCIENTIST
Alaeddine has an expertise in iPSC technology, Pharmacology, Neurobiology, and Drug Discovery. His passion for pharmacology began while completing his Doctor of Pharmacy in Algeria. Where a deep curiosity about how drugs affect human biology led him to pursue advanced training in France. There, he earned his PhD in pharmacology, cellular and molecular biology from Paris-Sud XI University. He completed two postdoctoral fellowships in neuroscience, first at the Institut de Pharmacologie Moléculaire et Cellulaire (IPMC) in France, where he helped characterize novel antidepressant compounds and contributed to the development of a patented therapeutic peptide. He then joined the University of Washington in Seattle as an acting instructor, where his research focused on synaptic plasticity and calcium channel regulation using electrophysiology and molecular biology approaches.
Most recently at Recursion Pharmaceuticals, he directed programs using iPSC-derived neuronal cell types for neurodegenerative disease modeling and high-throughput drug screening. With a background in electrophysiology, molecular pharmacology, and translational neuroscience, Alaeddine brings over a decade of research experience across academia and industry.
At BE Therapeutics, Alaeddine is a senior stem cell scientist with a focus on in vivo electrophysiology in rodents and in vitro characterization and development of stem cells and their use for brain regeneration.